Home Print this page Email this page Small font size Default font size Increase font size   Users Online: 103
Home About us Editorial board Search Browse articles Submit article Instructions Subscribe Contacts Login 
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 2-10

Biological response at the cellular level within the periodontal ligament on application of orthodontic force - An update

Departments of Orthodontics and Dentofacial Orthopedics, Priyadarshini Dental College and Hospital, Tamil Nadu, India

Correspondence Address:
Nazeer Ahmed Meeran
Old No 6, New No 11, NGO Colony First Street, Nanganallur, (Kendriya Vidyalaya School Road), Chennai - 600 114, Tamil Nadu
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0203.94769

Rights and Permissions

Orthodontic force elicits a biological response in the tissues surrounding the teeth, resulting in remodeling of the periodontal ligament and the alveolar bone. The force-induced tissue strain result in reorganization of both cellular and extracellular matrix, besides producing changes in the local vascularity. This in turn leads to the synthesis and release of various neurotransmitters, arachidonic acid, growth factors, metabolites, cytokines, colony-stimulating factors, and enzymes like cathepsin K, matrix metalloproteinases, and aspartate aminotransferase. Despite the availability of many studies in the orthodontic and related scientific literature, a concise integration of all data is still lacking. Such a consolidation of the rapidly accumulating scientific information should help in understanding the biological processes that underlie the phenomenon of tooth movement in response to mechanical loading. Therefore, the aim of this review was to describe the biological processes taking place at the molecular level on application of orthodontic force and to provide an update of the current literature.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded5077    
    Comments [Add]    
    Cited by others 12    

Recommend this journal