|
 
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| REVIEW ARTICLE |
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| Year : 2012 | Volume
: 1
| Issue : 4 | Page : 83-87 |
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Allergy and orthodontics
Sunitha Chakravarthi, Sridevi Padmanabhan, Arun B Chitharanjan
Department of Orthodontics, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
| Date of Web Publication | 11-Jan-2013 |
Correspondence Address:
Sunitha Chakravarthi
Department of Orthodontics, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai 600 116, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2278-0203.105871
The aim of this paper is to review the current literature on allergy in orthodontics and to identify the predisposing factors and the implications of the allergic reaction in the management of patients during orthodontic treatment. A computerized literature search was conducted in PubMed for articles published on allergy in relation to orthodontics. The MeSH term used was allergy and orthodontics. Allergic response to alloys in orthodontics, particularly nickel, has been extensively studied and several case reports of nickel-induced contact dermatitis have been documented. Current evidence suggests that the most common allergic reaction reported in orthodontics is related to nickel in orthodontic appliances and allergic response is more common in women due to a previous sensitizing exposure from nickel in jewellery. Studies have implicated allergy in the etiology of hypo-dontia. It has also been considered as a high-risk factor for development of extensive root resorption during the course of orthodontic treatment. This review discusses the relationship and implications of allergy in orthodontics. Keywords: Allergy, nickel, orthodontics
How to cite this article:
Chakravarthi S, Padmanabhan S, Chitharanjan AB. Allergy and orthodontics. J Orthodont Sci 2012;1:83-7 |
| Introduction | |  |
Allergic reactions are of increasing concern to practitioners in health-related fields. As patient susceptibility increases, the need for basic understanding and successful management of these conditions are of primary importance. An allergic response is one in which certain components of the immune system react excessively to a foreign substance. Allergy in patients undergoing orthodontic treatment can be seen due to several reasons and these include nickel allergy, allergy to the acrylic resins that are used during treatment, latex products, etc. [1] A large variety of metallic alloys are routinely used in dentistry. Allergy as a possible factor has also been implicated in root resorption and hypo-dontia.
Gold was used in orthodontics for fabrication of accessories until the 1930s and 1940s. In 1929, stainless steel was used for the first time to replace gold. Several metallic alloys are used in orthodontics, such as cobalt-chromium, nickel-titanium, β-titanium, among others; the majority of these alloys have nickel as one of their components. The percentage of this metal in the alloys varies from 8%, as in stainless steel, up to more than 50%, as in nickel-titanium alloys. The aim of this paper is to review and analyze critically the current available literature in the field of allergy in orthodontics and to provide clinical implications based on scientific evidence on the topic.
| Search Strategy | | |
A search was conducted on PubMed to retrieve all available literature on allergy and orthodontics. The search revealed a total of 114 articles on the topic. A total of 106 articles were retrieved in nickel allergy and orthodontics. Of these, 14 articles were reviews on nickel allergy and 92 were case reports. Four reviews were in languages other than English. These articles were eliminated and 10 articles were studied. Five articles were in relation to allergy and root resorption, and three were in relation to allergy and hypo-dontia.
| Nickel Allergy in Orthodontics | | |
Nickel is a powerful sensitizer metal and a common allergen. Dermatitis due to contact with nickel was first reported among workers in the nickel plating industry and was recognized as an allergic response in 1925. [2],[3] Nickel has often been pointed out as a biological sensitizer capable of causing short- and long-term sensitivity reactions. An increased risk of nickle sensitization in potential orthodontic patients could possibly be due to wearing Ni-containing jewellery at an early age. [4]
| Salivary Nickel Release from Fixed Appliances | | |
Park and Shearer [5] reported an average release of 40 μg of nickel and 36 μg of chromium from a simulated orthodontic appliance. The release of nickel is not necessarily related to the alloy's nickel content. [6] The amount of nickel release can increase during stress. The quantities released may be negligible from a toxicological point of view, but might conceivably be of significance for patients with a high degree of hypersensitivity to nickel. Fors and Persson [7] found significantly higher content of nickel in the plaque and saliva of patients with orthodontic appliances compared with non-orthodontic patients. Moreover, in orthodontic patients, significantly higher nickel content was found in plaque from metal surfaces (band and brackets) than from enamel surfaces.
| Biology of Nickel Allergy | | |
Elicitation of an allergic reaction to nickel depends on the conditions of nickel exposure-for example, hapten concentration on the contact area, open or occluded exposure, presence of an irritant, and degree of contact allergy. The elicitation threshold varies between patients and also individually over time. [8],[9] Nickel elicits contact dermatitis, which is a type-IV delayed hypersensitivity immune response. This process has two interrelated, distinct phases: [10] A sensitization phase occurs from the moment the allergen enters the body, is recognized, and a response occurs. The elicitation phase occurs after re-exposure to the allergen to appearance of the full clinical reaction. There may have been no symptoms at the initial exposure, but subsequent exposure leads to a more visible reaction. [11]
| Clinical Features Associated with Allergy | | |
Clinical abnormalities, such as gingivitis, gingival hyperplasia, lip desquamation, multiform erythema, burning sensation in the mouth, metallic taste, angular cheilitis, and periodontitis, may be associated with release of nickel from orthodontic appliances. [12],[13],[14],[15],[16] These reactions are associated with an inflammatory response induced by corrosion of orthodontic appliances and subsequent release of nickel. It is manifested as Nickel Allergic Contact Stomatitis (NiACS). A burning sensation is the most frequent symptom. The aspect of the affected mucosa is also variable, from slight erythema to shiny lesions, with or without edema. Vesicles are rarely observed, but when they are present, they quickly rupture, forming erosion areas. In chronic cases, the affected mucosa is typically in contact with the causal agent and appears erythematous or hyper-keratotic to ulcerated. [17] Other symptoms can also be present, such as peri-oral dermatitis and, rarely, orolingual paresthesia.
| Prevalence of Nickel Allergy | | |
The incidence of Ni-induced side effects from orthodontic materials in non-sensitized people is not known. It has also been suggested that the risk of sensitization from orthodontically derived Ni in these patients is extremely low. Nickel allergy is the most common contact allergy in industrialized countries; patch test verified data of general populations in several studies have shown that this allergy affects 10%-30% of females and 1-3% of males. [18],[19],[20],[21],[22] Two recent surveys from Europe estimated incidence of adverse patient reactions in orthodontic practice to be approximately 0.3%-0.4%. [23],[24] Kerosuo et al. [25] found prevalence of nickel allergy in Finnish adolescents to be 30% in girls and 3% in boys. This is thought to be due to ear piercing being a major cause of sensitization to nickel, as prevalence in subjects with pierced ears was 31% and those without pierced ears was 2%. [25]
People with cutaneous piercing were considered a significant risk factor for Ni allergy. [26] Scientific evidence suggests that orthodontic treatment is not associated with increase of Ni hypersensitivity, unless patients have a history of previous cutaneous piercing exposure to Ni, usually ear piercing. Previous allergic history has been significantly associated by several authors to a hypersensitivity response to nickel released from orthodontic appliances.
| Nickel Allergy and Periodontal Status | | |
Placement of orthodontic brackets influences the accumulation of biofilm and colonization of bacteria, thereby making a patient more prone to inflammation and bleeding. [27] Pazzini et al. found that nickel can influence inflammatory reactions throughout orthodontic treatment. Such reactions are characterized by gingival hyperplasia, changes in color and gingival bleeding upon probing. More than a direct sensitizing agent of skin and mucosa, nickel appears to alter the periodontal status, acting as a modifying factor of periodontal disease in sensitive patients. Results suggest a cumulative effect of nickel throughout orthodontic treatment and that this effect is associated with clinically significant periodontal abnormalities. [28]
Gursoy et al. [29] in 2007 found that low-dose continuing nickel release from orthodontic appliances might be the initiating factor for gingival overgrowth, as it has the capability of increasing epithelial cell proliferation. Pazzini et al. in 2011 found that patients treated with conventional braces exhibited greater periodontal alterations than those treated with nickel-free braces. Individuals with an allergy to nickel exhibit better periodontal health when treated with nickel-free braces than with conventional braces. [30] Pazzini et al. [31] found that nickel can influence the condition of the periodontal and blood cells of allergic orthodontic patients, but with reactions of an inflammatory, rather than allergic nature.
| Diagnosis | | |
Sensitivity to nickel has been evaluated through biocompatibility tests, [32] including cutaneous sensitivity (patch) tests, [33] and reactivity to nickel has been evaluated with in vitro cell proliferation assays. [34] It is important to make correct diagnosis of nickel allergy, symptoms of which may occur either within or remote to the oral environment. The signs and symptoms of nickel allergy are presented in [Table 1]. The following patient history would suggest a diagnosis of nickel allergy. [11]
- Previous allergic response after wearing earrings or a metal watchstrap;
- Appearance of allergy symptoms shortly after initial insertion of orthodontic components containing nickel;
- Confined extra-oral rash adjacent to headgear studs.
A dermatologist should confirm the diagnosis by patch testing using 5% nickel sulfate in petroleum jelly.
| Management of Nickel Allergy | | |
The majority of investigations have found that nickel-sensitive patients are able to tolerate stainless steel without any noticeable reaction. [35] Most research concludes that stainless steel is a safe material to use for all intra-oral orthodontic components for nickel-sensitive patients.
Alternatives to Nickel-Titanium Wires
Alternatives to Ni-Ti include twistflex stainless steel and fiber-reinforced composite archwires. Wires such as TMA, pure titanium, and gold-plated wires may also be used without risk. Altered nickel-titanium archwires also exist and include plastic/resin-coated nickel-titanium archwires. [36] Ion-implanted nickel-titanium archwires have their surface bombarded with nitrogen ions, which forms an amorphous surface layer, conferring corrosion resistance and displacing nickel atoms, and decreasing the risk of an allergic response.
Brackets
Stainless steel brackets are generally considered safe. However, nickel-free alternative brackets to stainless steel include:
- Ceramic brackets produced using polycrystalline alumina, single-crystal sapphire, and zirconia;
- Polycarbonate brackets that are produced from plastic polymers;
- Titanium brackets;
- Gold-plated brackets.
Extra-oral metal components, including metal studs in headgear, are of greatest concern due to greater sensitivity of skin. Plastic-coated headgear studs may be a better alternative for such patients.
| Allergy and Root Resorption | | |
Root resorption is a common sequel to orthodontic treatment and has been recorded in 93% of treated adolescents. [37] Davidovitch et al. [38] hypothesized that individuals who have medical conditions that affect the immune system may be at a high level of risk for developing excessive root resorption during the course of orthodontic treatment. In reviewing orthodontic patient records at the University of Oklahoma, they discovered that the incidence of asthma, allergies and signs indicative of psychological stress were significantly higher in patients who had experienced excessive root resorption during orthodontic treatment as compared with the group of orthodontic patients who had completed their course of treatment without suffering this unfortunate outcome.
McNab et al. [39] reported that the incidence of external apical root resorption was elevated in patients with asthma. However, both asthmatics and healthy patients exhibited similar amounts of moderate and severe resorption. Nishioka et al. [40] found that allergy and asthma might be an etiological factor in excessive root resorption. The same association was found in earlier studies. [37],[38],[39],[40],[41] Owman-Moll and Kurol [41] also suggested that there might be a link between allergy and the extent of root resorption, but no statistically significant difference was found. Nishioka et al. [40] strongly supported the hypothesis that allergy and asthma may be high-risk factors for development of excessive root resorption during orthodontic treatment. They concluded that allergy, root morphology abnormalities and asthma may be considered high-risk factors for development of excessive root resorption during the course of orthodontic treatment in a Japanese population.
| Allergy and Hypodontia | | |
Three articles were retrieved in the search and only one article dealt with allergy in relation to hypo-dontia. Third molars are the most commonly missing teeth followed by the second premolars and the maxillary lateral incisors. [42] The etiology of hypo-dontia is considered to be multifactorial, with genetics and environmental factors playing an important role. [43] Yamaguchi et al. [44] in 2008 studied 3683 Japanese orthodontic patients and found positive correlation between allergy and hypo-dontia. They concluded that health problems, especially those related to allergy, are of importance and could be strongly related to hypo-dontia.
| Conclusion | | |
Safe and effective practice depends on identifying patients with allergy along with knowledge of materials that can potentially cause them. It is imperative for a practitioner to not only know the physical and mechanical properties of the materials being used, but also of the biologic compatibility of the material. Knowledge of alternatives to allergy-causing materials is also of prime importance in efficient management of patients in routine clinical practice.
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[Table 1]
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